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Dulin, Nickolai
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overview Dr. Dulin’s laboratory investigates the signaling mechanisms of TGF-beta-induced myofibroblast differentiation as related to pathogenesis of pulmonary fibrosis, using cell culture and animal models of the disease. His studies have described the critical role for serum response factor (SRF) in myofibroblast differentiation and pulmonary fibrosis, as well as the control of this pathway by actin and microtubule dynamics. The other direction of Dr. Dulin research relates to the basic studies on the biological function of the regulators of G protein signaling (RGS) proteins, focusing on RGS3 member of the family. His group has shown that RGS3 regulates the signaling mediated by heterotrimeric Gi and Gq proteins, as well as non-canonically of TGF-beta signaling. Together with Dr. Anne Sperling, they established the role of RGS3 in control of T cell migration and T cell – mediated inflammation, using knock-down and knockout approaches. His current studies focus on the function of endogenous RGS3 as related to cancer cell growth, migration and EMT. Dr. Dulin's NIH Commons ID is NDULIN
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Item TypeName
Concept Amino Acid Chloromethyl Ketones
Concept Sodium-Potassium-Exchanging ATPase
Concept Histamine
Concept Kidney Neoplasms
Concept Hypertension
Concept Kidney Cortex
Concept Kidney Tubules, Proximal
Concept Heart Failure
Concept Hydrogen-Ion Concentration
Concept Hypertonic Solutions
Concept Hypertrophy
Concept Hypotonic Solutions
Concept Hypertension, Renal
Concept Immunohistochemistry
Concept HeLa Cells
Concept Kidney Tubules
Concept Protein-Tyrosine Kinases
Concept Protein Kinases
Concept Ion Exchange
Concept Hemodynamics
Concept Humans
Concept Hydroxyproline
Concept Sequence Homology, Amino Acid
Concept Kidney
Concept Sodium-Hydrogen Exchangers
Concept Guanine Nucleotide Exchange Factors
Concept Mitogen-Activated Protein Kinases
Concept NF-kappa B
Concept Receptors, HIV
Concept Bronchial Hyperreactivity
Concept Mice, Knockout
Concept Cyclic GMP-Dependent Protein Kinases
Concept Mitogen-Activated Protein Kinase 3
Concept Mitogen-Activated Protein Kinase Kinases
Concept Heterotrimeric GTP-Binding Proteins
Concept I-kappa B Proteins
Concept Protein Kinase C
Concept Glycine Hydroxymethyltransferase
Concept Glycogen Synthase Kinase 3
Concept HEK293 Cells
Concept Kruppel-Like Transcription Factors
Concept Wound Healing
Concept Mitogen-Activated Protein Kinase 1
Concept Calcium-Calmodulin-Dependent Protein Kinases
Concept A Kinase Anchor Proteins
Concept Gene Knockdown Techniques
Concept Homeodomain Proteins
Concept Phosphatidylinositol 3-Kinases
Concept alpha Karyopherins
Concept Two-Hybrid System Techniques
Concept MAP Kinase Signaling System
Concept Hydrozoa
Concept JNK Mitogen-Activated Protein Kinases
Concept Extracellular Signal-Regulated MAP Kinases
Concept Ribosomal Protein S6 Kinases, 70-kDa
Concept Cyclin-Dependent Kinase Inhibitor p27
Concept rho-Associated Kinases
Concept Immunochemistry
Concept Kidney Tubules, Collecting
Concept Kinetics
Concept Cyclic AMP-Dependent Protein Kinases
Concept Casein Kinase I
Concept p38 Mitogen-Activated Protein Kinases
Academic Article The human V3 pituitary vasopressin receptor: ligand binding profile and density-dependent signaling pathways.
Academic Article Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways.
Academic Article Phospholipase A2-mediated activation of mitogen-activated protein kinase by angiotensin II.
Academic Article Role of phospholipase A2 isozymes in agonist-mediated signaling in proximal tubular epithelium.
Academic Article Cyclic AMP-independent activation of protein kinase A by vasoactive peptides.
Academic Article RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11.
Academic Article Signal transduction pathways of the human V1-vascular, V2-renal, V3-pituitary vasopressin and oxytocin receptors.
Academic Article Activation of cAMP signaling transiently inhibits apoptosis in vascular smooth muscle cells in a site upstream of caspase-3.
Academic Article G-protein-coupled-receptor activation of the smooth muscle calponin gene.
Academic Article Arachidonate-induced tyrosine phosphorylation of epidermal growth factor receptor and Shc-Grb2-Sos association.
Academic Article ATP-induced inhibition of Na+, K+, Cl- cotransport in Madin-Darby canine kidney cells: lack of involvement of known purinoceptor-coupled signaling pathways.
Academic Article Inversion of the intracellular Na(+)/K(+) ratio blocks apoptosis in vascular smooth muscle cells by induction of RNA synthesis.
Academic Article Antiproliferative effect of brief exposure to cholera toxin in vascular smooth muscle cells: role of cAMP and protein kinase A.
Academic Article Inhibition of NFkappaB induces caspase-independent cell death in human T lymphocytes.
Academic Article Mechanism of apoptosis induced by zinc deficiency in peripheral blood T lymphocytes.
Academic Article A mechanism of calcium binding by the erythrocyte skeleton: some features in primary hypertension.
Academic Article Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.
Academic Article Activation of cGMP-dependent protein kinase by protein kinase C.
Academic Article Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway.
Academic Article RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain.
Academic Article [Calcium binding to the erythrocyte cytoskeleton in spontaneously hypertensive rats].
Academic Article Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway.
Academic Article Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA.
Academic Article Serum response factor function and dysfunction in smooth muscle.
Academic Article Dual role of PKA in phenotypic modulation of vascular smooth muscle cells by extracellular ATP.
Academic Article c-Fos expression in ouabain-treated vascular smooth muscle cells from rat aorta: evidence for an intracellular-sodium-mediated, calcium-independent mechanism.
Academic Article Renal carcinoma cells undergo apoptosis without oligonucleosomal DNA fragmentation.
Academic Article Regulation of serum response factor-dependent gene expression by proteasome inhibitors.
Academic Article What evidence implicates airway smooth muscle in the cause of BHR?
Academic Article Cl- secretion in ATP-treated renal epithelial C7-MDCK cells is mediated by activation of P 2Y1 receptors, phospholipase A2 and protein kinase A.
Academic Article Purinergic inhibition of Na?,K?,Cl? cotransport in C11-MDCK cells: Role of stress-activated protein kinases.
Academic Article Cell-volume-dependent vascular smooth muscle contraction: role of Na+, K+, 2Cl- cotransport, intracellular Cl- and L-type Ca2+ channels.
Academic Article Phosphorylation of beta-catenin by PKA promotes ATP-induced proliferation of vascular smooth muscle cells.
Academic Article Phosphorylation of myocardin by extracellular signal-regulated kinase.
Academic Article Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein.
Academic Article MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle.
Academic Article Protein kinase C activity in erythrocytes in primary hypertension: regulation of cell shape and cation transport.
Academic Article PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4.
Academic Article Non-canonical functions of RGS proteins.
Academic Article [The role of protein phosphorylation in mast cell secretion, stimulated by concanavalin A. Connection to the cytoskeleton].
Academic Article [Na]i -induced c-Fos expression is not mediated by activation of the 5' -promoter containing known transcriptional elements.
Academic Article Priming with very low-affinity peptide ligands gives rise to CD8(+) T-cell effectors with enhanced function but with greater susceptibility to transforming growth factor (TGF)ß-mediated suppression.
Academic Article CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation.
Academic Article [Protein kinase C activity in the brain tissue of spontaneously hypertensive rats].
Academic Article Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis.
Academic Article [Regulation of the shape and size of human erythrocytes by protein kinases A and C].
Academic Article Steroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma.
Academic Article Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-ß.
Academic Article Actin cytoskeleton in myofibroblast differentiation: ultrastructure defining form and driving function.
Academic Article [Changes in erythrocyte volume in relation to characteristics of protein phosphorylation of the membrane cytoskeleton in hypertension: role of protein kinase C].
Academic Article Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle.
Academic Article Rabbit renal epithelial angiotensin II receptors.
Academic Article Angiotensin IV receptors and signaling in opossum kidney cells.
Academic Article Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta.
Academic Article A finer tuning of G-protein signaling through regulated control of RGS proteins.
Academic Article [Protein kinase A and C activity of erythrocytes in patients with essential hypertension].
Academic Article Purinergic modulation of Na(+),K(+),Cl(-) cotransport and MAP kinases is limited to C11-MDCK cells resembling intercalated cells from collecting ducts.
Academic Article Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis.
Academic Article Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation.
Academic Article Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase.
Academic Article Downregulation of smooth muscle alpha-actin expression by bacterial lipopolysaccharide.
Academic Article Gbetagamma-mediated prostacyclin production and cAMP-dependent protein kinase activation by endothelin-1 promotes vascular smooth muscle cell hypertrophy through inhibition of glycogen synthase kinase-3.
Academic Article Regulation of Smad-mediated gene transcription by RGS3.
Academic Article Nuclear import of serum response factor in airway smooth muscle.
Academic Article Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart.
Academic Article Activity of protein kinase C in erythrocytes in primary hypertension.
Academic Article RGS expression in cancer: oncomining the cancer microarray data.
Academic Article Control of myofibroblast differentiation by microtubule dynamics through a regulated localization of mDia2.
Academic Article Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin.
Academic Article RGS3 controls T lymphocyte migration in a model of Th2-mediated airway inflammation.
Academic Article Antifibrotic effects of noscapine through activation of prostaglandin E2 receptors and protein kinase A.
Academic Article Cation-chloride cotransporters: regulation, physiological significance, and role in pathogenesis of arterial hypertension.
Academic Article Organizer regions in marine colonial hydrozoans.
Academic Article Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis.
Academic Article Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces.
Academic Article Critical role of the a1-Na(+), K(+)-ATPase subunit in insensitivity of rodent cells to cytotoxic action of ouabain.
Academic Article Regulation of myofibroblast differentiation by cardiac glycosides.
Academic Article SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.
Academic Article Transforming Growth Factor (TGF)-ß Promotes de Novo Serine Synthesis for Collagen Production.
Academic Article Downregulation of TGF-ß Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase.
Academic Article NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension.
Academic Article Control of Myofibroblast Differentiation and Function by Cytoskeletal Signaling.
Academic Article Na+,K+-ATPase as a Target for Treatment of Tissue Fibrosis.
Academic Article Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
Academic Article P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-ß1, -ß2, and -ß3 Translation.
Academic Article Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation.
Academic Article Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.
Academic Article Sustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-ß.
Academic Article Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
Academic Article Control of lung myofibroblast transformation by monovalent ion transporters.
Academic Article Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling.
Academic Article Na,K-ATPase as a target for endogenous cardiotonic steroids: What's the evidence?
Academic Article Identification of a Cardiac Glycoside Exhibiting Favorable Brain Bioavailability and Potency for Reducing Levels of the Cellular Prion Protein.
Concept NF-KappaB Inhibitor alpha
Concept Glycogen Synthase Kinase 3 beta
Concept Protein Kinase C-theta
Concept Cyclic GMP-Dependent Protein Kinase Type I
Grant Fibroblast Biology and Pulmonary Fibrosis
Grant Activation of protein kinase A by endothelin-1
Grant Control of myofibroblast activation and pulmonary fibrosis by Na/K-ATPase
Grant Novel functions of RGS3
Academic Article Anoctamin-1 is induced by TGF-ß and contributes to lung myofibroblast differentiation.
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